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MerckPatent grant

Merck Sharp & Dohme was granted a patent for nitrosamine testing.

What happened

In September 2026 Merck Sharp & Dohme patented a rapid quality-control method for detecting trace nitrosamines in solid pharmaceutical samples.

Source

Abstract

This invention describes a novel method encompassing preparing a nitrosamine sample, adding in relevant chemicals that reduces or eliminates in situ nitrosamine formation, utilizing full evaporation static headspace gas chromatograph coupled with nitrogen phosphorous detector (FE-SHSGC-NPD), and analysis of rapid results in the gaseous phase for sensitive detection of semi-volatile nitrosamines, including NDMA.

patents.google.com/patent/US12730096Read the full source

Extracted by Autobound

From the Signal API record
Signal
Patent grant

What this signalsA new patent often shows where a company is putting its R&D budget.

Grant date
Sep 8, 2026
Inventors
4
Patent number
US12730096
Assignee
Merck Sharp & Dohme

The full record

From the Signal API record

People

  • Rebecca EvansInventor
  • Xinxin HanInventor
  • Daniel E. LeeInventor
  • Christine L. RadichInventor
  • Jinjian ZhengInventor

Details

Primary CPC class
G01N 30/30
USPTO assignee
Merck Sharp & Dohme
What the invention does
A testing process that prevents nitrosamines from forming during preparation, vaporizes the sample, and measures the compounds with gas chromatography and a nitrogen-sensitive detector.

Topics and mentions

Tags

  • Intellectual Property
  • Research & Development
  • Chemical Engineering
  • Quality Assurance

Technologies named

  • nitrosamine analysis
  • gas chromatography
  • headspace sampling
  • pharmaceutical quality control

Extraction

Detected
Sep 15, 2026
signal_type
patents-company
signal_subtype
patentGrant

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The API returns more than this page shows

This page shows a preview. The full patents-company record in the Signal API and MCP can also have these 8 fields. Some fields are empty for some signals.

Company

  • linkedin_urlValue in the API
  • industriesValue in the API
  • employee_count_lowValue in the API
  • employee_count_highValue in the API
  • revenueValue in the API
  • descriptionValue in the API

Signal

  • signal_nameValue in the API
  • associationValue in the API
Show the full JSONThe record on this page and the API request

GET /v1/signals/f5da121b-be74-54b1-b87d-5e476a809cb7 returns this record as JSON. POST /v1/companies/enrich returns every signal for merck.com.

{
  "signal_id": "f5da121b-be74-54b1-b87d-5e476a809cb7",
  "signal_type": "patents-company",
  "signal_subtype": "patentGrant",
  "detected_at": "2026-09-15T03:10:46+00:00",
  "company": {
    "name": "Merck",
    "domain": "merck.com"
  },
  "data": {
    "cpc": [
      {
        "code": "G01N 30/30"
      },
      {
        "code": "G01N 30/14"
      },
      {
        "code": "G01N 30/62"
      },
      {
        "code": "G01N 30/7206"
      },
      {
        "code": "G01N 33/15"
      }
    ],
    "tags": [
      "Intellectual Property",
      "Research & Development",
      "Chemical Engineering",
      "Quality Assurance"
    ],
    "detail": "In September 2026 Merck Sharp & Dohme patented a rapid quality-control method for detecting trace nitrosamines in solid pharmaceutical samples.",
    "summary": "Merck Sharp & Dohme was granted a patent for nitrosamine testing.",
    "event_at": "2026-09-08",
    "inventors": [
      {
        "name": "Rebecca Evans",
        "status": "unresolved",
        "is_primary": true
      },
      {
        "name": "Xinxin Han",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/xinxin-han-90322031"
      },
      {
        "name": "Daniel E. Lee",
        "status": "unresolved",
        "is_primary": false
      },
      {
        "name": "Christine L. Radich",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/christine-kirkpatrick"
      },
      {
        "name": "Jinjian Zheng",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/jinjianzheng"
      }
    ],
    "event_kind": "grant_date",
    "grant_date": "2026-09-08",
    "source_url": "https://patents.google.com/patent/US12730096",
    "cpc_primary": {
      "code": "G01N 30/30"
    },
    "patent_title": "Method for analyzing trace levels of semi-volatile nitrosamines in solid samples",
    "patent_number": "US12730096",
    "uspto_assignee": "Merck Sharp & Dohme",
    "patent_abstract": "This invention describes a novel method encompassing preparing a nitrosamine sample, adding in relevant chemicals that reduces or eliminates in situ nitrosamine formation, utilizing full evaporation static headspace gas chromatograph coupled with nitrogen phosphorous detector (FE-SHSGC-NPD), and analysis of rapid results in the gaseous phase for sensitive detection of semi-volatile nitrosamines, including NDMA.",
    "precision_class": "structural",
    "invention_explanation": "A testing process that prevents nitrosamines from forming during preparation, vaporizes the sample, and measures the compounds with gas chromatography and a nitrogen-sensitive detector.",
    "technologies_mentioned": [
      "nitrosamine analysis",
      "gas chromatography",
      "headspace sampling",
      "pharmaceutical quality control"
    ]
  }
}

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