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RegeneronPatent grant

Regeneron was granted a patent for bispecific antibodies targeting tumors.

What happened

In September 2026 Regeneron patented antibody treatments designed to direct T cells against cancer cells while limiting unwanted immune activity, for oncology research and therapy.

Source

patents.google.comSep 29, 2026

US patent US12747300

Methods and antibody compositions for tumor treatment

Abstract

The present invention provides bispecific antibodies that bind to CD3 and tumor antigens and methods of using the same. According to certain embodiments, the bispecific antibodies of the invention exhibit reduced effector functions and have a unique binding profile with regard to Fcγ receptors. The bispecific antibodies are engineered to efficiently induce T cell-mediated killing of tumor cells. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, a second antigen-binding molecule that specifically binds human CD20, and an Fc domain that binds Fcγ receptors with a specific binding pattern. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of B-cell or melanoma tumors expressing CD20. The bispecific antibodies of the invention are useful for the treatment of various cancers as well as other CD20-related diseases and disorders.

patents.google.com/patent/US12747300Read the full source

Extracted by Autobound

From the Signal API record
Signal
Patent grant

What this signalsA new patent often shows where a company is putting its R&D budget.

Grant date
Sep 29, 2026
Inventors
4
Patent number
US12747300
Assignee
Regeneron Pharmaceuticals, Inc.

The full record

From the Signal API record

People

  • Eric SmithInventor
  • Samuel DavisInventor
  • Bindu VargheseInventor
  • Jessica R. KirshnerInventor
  • Gavin ThurstonInventor

Details

Primary CPC class
C07K 16/2887
USPTO assignee
Regeneron Pharmaceuticals, Inc.
What the invention does
Engineered antibodies that attach to both T cells and tumor markers, bringing the cells together to destroy cancer while reducing other immune effects.

Topics and mentions

Tags

  • Intellectual Property
  • Research & Development
  • Pharmaceuticals
  • Medical Research

Technologies named

  • bispecific antibodies
  • immuno-oncology
  • T-cell therapies
  • Fc receptor engineering

Extraction

Detected
Sep 30, 2026
signal_type
patents-company
signal_subtype
patentGrant

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This page shows a preview. The full patents-company record in the Signal API and MCP can also have these 8 fields. Some fields are empty for some signals.

Company

  • linkedin_urlValue in the API
  • industriesValue in the API
  • employee_count_lowValue in the API
  • employee_count_highValue in the API
  • revenueValue in the API
  • descriptionValue in the API

Signal

  • signal_nameValue in the API
  • associationValue in the API
Show the full JSONThe record on this page and the API request

GET /v1/signals/4a5b8e08-ca7d-51d3-99aa-1fb93632410b returns this record as JSON. POST /v1/companies/enrich returns every signal for regeneron.com.

{
  "signal_id": "4a5b8e08-ca7d-51d3-99aa-1fb93632410b",
  "signal_type": "patents-company",
  "signal_subtype": "patentGrant",
  "detected_at": "2026-09-30T16:59:02+00:00",
  "company": {
    "name": "Regeneron",
    "domain": "regeneron.com"
  },
  "data": {
    "cpc": [
      {
        "code": "C07K 16/2887"
      },
      {
        "code": "C07K 16/2803"
      },
      {
        "code": "C07K 16/2809"
      },
      {
        "code": "A61K 2039/505"
      },
      {
        "code": "C07K 2317/24"
      }
    ],
    "tags": [
      "Intellectual Property",
      "Research & Development",
      "Pharmaceuticals",
      "Medical Research"
    ],
    "detail": "In September 2026 Regeneron patented antibody treatments designed to direct T cells against cancer cells while limiting unwanted immune activity, for oncology research and therapy.",
    "summary": "Regeneron was granted a patent for bispecific antibodies targeting tumors.",
    "event_at": "2026-09-29",
    "inventors": [
      {
        "name": "Eric Smith",
        "status": "unresolved",
        "is_primary": true
      },
      {
        "name": "Samuel Davis",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/samuel-davis-0225316"
      },
      {
        "name": "Bindu Varghese",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/bindu-varghese"
      },
      {
        "name": "Jessica R. Kirshner",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/jessica-kirshner-4533b8"
      },
      {
        "name": "Gavin Thurston",
        "status": "resolved",
        "is_primary": false,
        "linkedin_url": "https://www.linkedin.com/in/gavin-thurston-77518219b"
      }
    ],
    "event_kind": "grant_date",
    "grant_date": "2026-09-29",
    "source_url": "https://patents.google.com/patent/US12747300",
    "cpc_primary": {
      "code": "C07K 16/2887"
    },
    "patent_title": "Methods and antibody compositions for tumor treatment",
    "patent_number": "US12747300",
    "uspto_assignee": "Regeneron Pharmaceuticals, Inc.",
    "patent_abstract": "The present invention provides bispecific antibodies that bind to CD3 and tumor antigens and methods of using the same. According to certain embodiments, the bispecific antibodies of the invention exhibit reduced effector functions and have a unique binding profile with regard to Fcγ receptors. The bispecific antibodies are engineered to efficiently induce T cell-mediated killing of tumor cells. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, a second antigen-binding molecule that specifically binds human CD20, and an Fc domain that binds Fcγ receptors with a specific binding pattern. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of B-cell or melanoma tumors expressing CD20. The bispecific antibodies of the invention are useful for the treatment of various cancers as well as other CD20-related diseases and disorders.",
    "precision_class": "structural",
    "invention_explanation": "Engineered antibodies that attach to both T cells and tumor markers, bringing the cells together to destroy cancer while reducing other immune effects.",
    "technologies_mentioned": [
      "bispecific antibodies",
      "immuno-oncology",
      "T-cell therapies",
      "Fc receptor engineering"
    ]
  }
}

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