SandboxAQ launches Virtual Screening Solution for GPCR Drug Discovery, accelerated by NVIDIA BioNeMo.
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SandboxAQ launches Virtual Screening Solution for GPCR Drug Discovery, accelerated by NVIDIA BioNeMo. Jun 23, 2026, 09:00 ET PALO ALTO, Calif., June 23, 2026 /PRNewswire/ - SandboxAQ today announced a new virtual screening solution that helps drug developers identify promising candidates faster and at lower cost for G protein-coupled receptors (GPCRs), one of the most valuable yet hardest-to-drug families of targets. Accelerated by NVIDIA BioNeMo Agent Toolkit, the GPCR Virtual Screening Solution predicts both whether a molecule binds a receptor and whether it is likely to activate the receptor or block its activation. GPCRs are the targets of roughly a third of all approved drugs, including the GLP-1 medicines for diabetes and obesity, yet they remain notoriously difficult to drug. Because these receptors can shift between "on" and "off" states, a successful medicine must not only bind, but bind in a way that stabilizes the right state and produces the desired biological effect. That is where the GPCR Virtual Screening Solution can help. It helps researchers predict what a GPCR ligand, whether a small molecule or peptide, will do - not just whether it binds. By forecasting how tightly a molecule binds to different receptor conformations and modeling its preference for the receptor's active versus inactive state, the Virtual Screening Solution infers functional activity...
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