TerraPower commits $450M to build radioisotope production plant.
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TerraPower commits $450M to build radioisotope production plant. March 18, 2026 | Constructing the cGMP facility will increase availability of actinium-225, a nuclear material central to radiopharmaceutical programs at AstraZeneca, Bristol Myers Squibb, Eli Lilly and Novartis. TerraPower Isotopes has committed $450 million to build a manufacturing facility in Philadelphia, setting the company up to increase production capacity for a key radioisotope by 20-fold. The company, which was co-founded by Bill Gates, is working to increase availability of the alpha-emitting isotope actinium-225. Because actinium-225 emits more energy than lutetium-177, the beta-emitting isotope in Novartis' Lutathera and Pluvicto, companies have identified the nuclear material as an enabler of next-generation radioligand therapies. Rising demand has stretched supply, leading Bristol Myers Squibb's RayzeBio to pause a Phase 3 trial over a shortage of actinium-225 in 2024. The situation has led companies including TerraPower to invest in capacity to make actinium-225. Suppliers are investing in production to support deals with AstraZeneca, Bayer and other drugmakers that are advancing radioisotope-based cancer therapies. February 17, 2026 Having initially served the market from Washington State, TerraPower announced Tuesday that it is establishing a presence on the East Coast by building a...
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