A user is troubleshooting a Waters Acquity M-Class FL Sample Manager that is failing to deliver samples, reporting that every run appears to be solvent only despite the unit passing all built-in...

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  "detected_at": "2026-09-25T13:47:15+00:00",
  "company": {
    "name": "Waters",
    "domain": "waters.com"
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    "topics": [
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    "post_id": "1wpwsuf",
    "summary": "A user is troubleshooting a Waters Acquity M-Class FL Sample Manager that is failing to deliver samples, reporting that every run appears to be solvent only despite the unit passing all built-in diagnostic tests.",
    "category": "reliability",
    "comments": [
      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wpwsuf/comment/pbz4vd2/",
        "depth": 0,
        "score": 3,
        "author": "viomoo",
        "excerpt": "You can do a weight test to confirm it’s actually drawing sample out of the vial.\n\n Also, do a leak test with the loop in line to see if you are losing anything that way.\n\n Have you calibrated the air sensor already? A lot of people get confused with that and leave it attached to the system which messes everything up. You need to disconnect and remove the droplet that forms in order to get accurat",
        "posted_at": "2026-09-25T14:10:40.000Z",
        "author_url": "https://www.reddit.com/user/viomoo/"
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      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wpwsuf/comment/pbzk4zf/",
        "depth": 0,
        "score": 2,
        "author": "Nasibakker",
        "excerpt": "Weak wash needs enough water to get a proper air bubble. At least 50% I think.\n\n If you repeat the calibrate needle and loop volume, do you get the same results? If so then the injector is able to accurately place a sample in the loop. If not it could be a loose connection on the needle or air in syringe.",
        "posted_at": "2026-09-25T15:16:18.000Z",
        "author_url": "https://www.reddit.com/user/Nasibakker/"
      },
      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wpwsuf/comment/pc3zqnk/",
        "depth": 0,
        "score": 2,
        "author": "Jesman89",
        "excerpt": "Cómo sabes que la falla es el sample manager?",
        "posted_at": "2026-09-26T04:21:52.000Z",
        "author_url": "https://www.reddit.com/user/Jesman89/"
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      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wpwsuf/comment/pbz2l85/",
        "depth": 0,
        "score": 1,
        "author": "Top_Occasion_1467",
        "excerpt": "try to use the dilution feature to back flush injector?",
        "posted_at": "2026-09-25T14:00:16.000Z",
        "author_url": "https://www.reddit.com/user/Top_Occasion_1467/"
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      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wpwsuf/comment/pc29p87/",
        "depth": 0,
        "score": 1,
        "author": "Aska2020",
        "excerpt": "I'm not familiar with M class but in older model you can see if the metering syringe is actually drawing the sample. Do you see the liquid actually aspirating? Also, what mode of injection are you using, full loop, plno, plpa? Does changing the injection mode makes any difference? Sounds like you are using MS. How did you isolate that the issue is on SM? Did you check your MS setting incl. fluidic",
        "posted_at": "2026-09-25T22:26:02.000Z",
        "author_url": "https://www.reddit.com/user/Aska2020/"
      }
    ],
    "evidence": [
      "[post] My M class fixed loop sample manager is not delivering sample, every run looks like the solvent only.",
      "[post] The sample manager passes all the built in tests for seals, needle loop volume calibration, etc.",
      "[post] The only \"anomaly\" is that I had to increase the air bubble size in order to get it to measure the needle and loop volumes. Any suggestions would be appreciated!"
    ],
    "virality": "low",
    "post_date": "2026-09-25T13:47:15.000Z",
    "post_kind": "text",
    "post_text": "My M class fixed loop sample manager is not delivering sample, every run looks like the solvent only. Detector is working (lockmass is A-OK) and I can see the increasing AcN gradient. As far as I can discern the mechanical movements are all OK and I have checked and reset the Z-height. The sample manager passes all the built in tests for seals, needle loop volume calibration, etc. By removing and using a syringe pump I have determined that the needle and loop are both clear. I have tested the inlet valve for clear passage between all 3 pairs of ports in both load and inject positions. The sample pressure during injection reads about 160 psi. The only \"anomaly\" is that I had to increase the air bubble size in order to get it to measure the needle and loop volumes. Any suggestions would be appreciated!",
    "sentiment": "negative",
    "subreddit": "massspectrometry",
    "event_date": "2026-09",
    "post_title": "Troubleshooting Acquity FL Sample Manager",
    "prominence": "core",
    "source_url": "https://www.reddit.com/r/massspectrometry/comments/1wpwsuf/troubleshooting_acquity_fl_sample_manager/",
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    "comments_total": 7,
    "total_comments": 7,
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    "products_mentioned": [
      "Acquity FL Sample Manager",
      "Acquity M-Class"
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curl https://signals.autobound.ai/v1/signals/063090e6-6932-56fc-a626-77f3114e89eb \
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curl -X POST https://signals.autobound.ai/v1/companies/enrich \
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  -H "Content-Type: application/json" \
  -d '{"domain":"waters.com","limit":20}'