A user of a Waters Synapt G2-Si mass spectrometer is experiencing a regularly pulsing and unstable electrospray signal, where the signal repeatedly drops out and returns during acquisition.

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    "summary": "A user of a Waters Synapt G2-Si mass spectrometer is experiencing a regularly pulsing and unstable electrospray signal, where the signal repeatedly drops out and returns during acquisition.",
    "category": "reliability",
    "comments": [
      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wjbqvj/comment/pahemzw/",
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        "score": 4,
        "author": "viomoo",
        "excerpt": "How does the spray look? It sounds like you have a blocked capillary or something could be going on with the nebulizer gas supply etc.\n\n You can set the reference spray going and monitor it in masslynx over a long period of time to isolate the analytical probe and then repeat with a flow from the analytical sprayer to see if it is the same.\n\n When you say the signal drops out is it to zero or is t",
        "posted_at": "2026-09-18T01:03:13.000Z",
        "author_url": "https://www.reddit.com/user/viomoo/"
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      {
        "url": "https://www.reddit.com/r/massspectrometry/comments/1wjbqvj/comment/paijsb2/",
        "depth": 0,
        "score": 2,
        "author": "orangepotatocatgeek",
        "excerpt": "I had a similar problem, the culprit was a partially clogged fret right at the connection with the source. After sonication it went away.",
        "posted_at": "2026-09-18T05:08:30.000Z",
        "author_url": "https://www.reddit.com/user/orangepotatocatgeek/"
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        "url": "https://www.reddit.com/r/massspectrometry/comments/1wjbqvj/comment/paiuzaw/",
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        "author": "Megalomania192",
        "excerpt": "Does the time between signal drops change if you change the sample flow rate? If yes think HPLC/fluidics issue if no then mass spec hardware issue.\n\n Are you running a lockmass? Infuse the lock mass for 5 mins. Does it look the same? Or run anything through the reference capillary.\n\n That’ll help you narrow it down at least.",
        "posted_at": "2026-09-18T06:36:34.000Z",
        "author_url": "https://www.reddit.com/user/Megalomania192/"
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    "evidence": [
      "[post] Regular Pulsing and Unstable Electrospray Signal on Waters Synapt G2-Si - Any Ideas?",
      "[post] I’m experiencing a pulsing and unstable electrospray signal on a Waters Synapt G2-Si. The signal initially appears normally, but after some time it completely drops out. It then comes back, runs for a while, and drops out again.",
      "[post] Interestingly, the periods with no signal seem to last approximately the same amount of time throughout the acquisition, so the pulsing appears fairly regular."
    ],
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    "post_date": "2026-09-18T00:54:25.000Z",
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    "post_text": "Hi everyone,I’m experiencing a pulsing and unstable electrospray signal on a Waters Synapt G2-Si. The signal initially appears normally, but after some time it completely drops out. It then comes back, runs for a while, and drops out again.Interestingly, the periods with no signal seem to last approximately the same amount of time throughout the acquisition, so the pulsing appears fairly regular.Has anyone experienced a similar issue on a Synapt G2-Si? What could cause this, and what settings or hardware components should I check?Any suggestions would be greatly appreciated. Thank you!",
    "sentiment": "negative",
    "subreddit": "massspectrometry",
    "event_date": "2026-09",
    "post_title": "Regular Pulsing and Unstable Electrospray Signal on Waters Synapt G2-Si - Any Ideas?",
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    "source_url": "https://www.reddit.com/r/massspectrometry/comments/1wjbqvj/regular_pulsing_and_unstable_electrospray_signal/",
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